I sometimes get a popup “Zwift Is Not Responding”, why?
Gnome (Mutter) has a standard timeout of 5 seconds in which it expects applications to respond. This is often not enough when launching heavier applications such as a game.

The solution is to simply extend the timeout or disable it entirely.
To extend the timeout to 1 minute (recommended):
foo@bar:~$ gsettings set org.gnome.mutter check-alive-timeout 60000
To disable the timeout entirely:
foo@bar:~$ gsettings set org.gnome.mutter check-alive-timeout 0